Main topics
WP1 - Environmental contributions to mucosal homeostasis
➜ How early life nutrition shapes intestinal microbiota and long-term health
➜ Strengthening of the intestinal barrier through nutrition
➜ Molecular mechanism and risk factors for oesophageal atresia
➜ Mucosal barrier homeostasis and mucus protective role
➜ Epidemiological investigations to explore IBD evolution
➜ Identifying new causal and aggravating factors for IBD
➜ Experimental evaluation of environmental risk factors for inflammatory bowel diseases
➜ Pathobionts and microbiota-targeting therapies in IBD
WP2 - Epithelium integrity: from pathologic regeneration to homeostasis
➜ Defective hepatocyte compartment in alcohol-associated hepatitis (AH) liver and cross-talks with the nonparenchymal cells
➜ Evaluation of innovative strategies to help public health decision-makers to combat chronic liver diseases
➜ AU-rich Elements Binding proteins as new actors and potential therapeutic targets for chronic liver disease and their cancer complications
➜ Post-transcriptional regulation of gene expression and chronic liver diseases
WP3 - From chronic inflammation to fibrosis: Role of immune cells
➜ Adaptive immunity in IBD: Seeking for the roles of B and T lymphocytes in chronic inflammation, fibrosis and colitis-associated colorectal cancer
➜ CAR-T cells: Identifying cellular and molecular determinants of inflammatory adverse events, efficacy, and resistance in patients undergoing CAR-T therapy
➜ Characterization and role of eosinophils in inflammatory diseases and tissue remodelling