WP3 - From chronic inflammation to fibrosis : role of immune cells
From chronic inflammation to fibrosis: to decipher the role of immune cells in maintaining and reviving inflammation in chronic inflammatory diseases and to evaluate their influence in fibrosis
The WP3 aims to identify and characterize pathological immune cells, which are responsible for the maintenance of chronic inflammation and consequent fibrosis development.
Chronic inflammatory diseases are characterized by sustained inflammation leading to fibrosis, organ dysfunction and high morbidity and mortality. T and B lymphocytes play key roles through cytokine secretion and auto-antibody production. The regulatory dysfunction of innate immune cells like eosinophils also contributes to sustained inflammation and tissue remodeling. Our research delves into the immune mechanisms and cell interactions in prototypical inflammatory and fibrotic diseases like IBD and SSc, focusing on B cells, T cells, and eosinophils to unearth the immunological roots of chronic inflammation and subsequent fibrosis.
INFINITE combines interdisciplinary approaches, innovative models and leverages comprehensive patient data and biobanks to advance understanding and treatment strategies, targeting the significant challenge of fibrosis in chronic inflammatory conditions.